There was already an exception for the project folder for Windows Defender Scanning. What did change that we had set before was Windows Data Execution Protection. Typically we put an exception for this for PAC Display to prevent random crashing. It looks like this is in a different location now in newer releases of Win10 (we disabled it, but still had the issue).
There are also some other ‘Exploit Protection Settings’ that can be turned off in that section, so I made an exception for PAC Display runtime and turned off everything that was on by default. I just did that, and the issue hasn’t reproduced itself yet, but we will continue to test over the next few days.
Windows Security
App & Browser Control
Exploit Protection Settings
Program Settings
Add an exception for program name DisplayR.pro.exe
Set overide to off on all settings that are normally on